Table 2.

Assessment of permeants delivered into the eye based on the 40 mM Mn²⁺ and 0.1 M MnEDTA²⁻ MRI studies in vivo^a

Experiment	Anterior chamber	Ciliary body/posterior chamber near site of application	Vitreous near site of application
Passive deliveryb	–	–	–
Subconjunctival injectionc	–	–	–
20-min transscleral iontophoresis near the fornix at 2 mA	–	–	–d
20-min transscleral iontophoresis at the pars plana at 2 mA	xxx	xx	x
60-min transscleral iontophoresis at the pars plana at 2 mA	xxx	xxx	xxx
20-min transscleral iontophoresis at the pars plana at 4 mA	xxx	xx	x

^a–, undetectable: below 0.02 mM; x, trace amount: 0.02–0.08 mM; xx, small amount: 0.08–0.3 mM; xxx, substantial amount: 0.3–2 mM; in the ROIs for Mn²⁺ and MnEDTA²⁻.

^bFrom Li et al. (2004a).

^cFrom Li et al. (2004b).

^dSubjected to the location of the ROI and the interpretation of the data.