Table 1.
G protein α subunit effector systems identified by functional and direct interactiona
| α-Subunits | Effector | Effect-Comment |
|---|---|---|
| Gsα | AC I through VII, also AC IX | Stimulation |
| Caveolin | Subcellular localization | |
| Golfα | Most likely all ACs | |
| Gi1α through | All Acs except | Inhibition |
| Gi3α | AC II and IV | |
| AC IX not tested | ||
| αi2 | Kir 6: :SUR | Stimulation by reducing inhibition by ATP |
| αI1 | PI3 kinase γ | Stimulation |
| Goα | ||
| αo | AC I (not AC V or VI) | Inhibition |
| αi/o | rap1-GAPII (GoLoco domain) | Promotes degradation of rap1-GAPII |
| αo | PKAcat α and β | Sequestration in extranuclear compartment |
| Gtα rod, cone | PDE6γ subunit | Releases inhibition of cGMP-specific PDEαβ by PDE |
| Ggustα | cAMP-specific Ca/CaM-stimulated PDE1Ab | Stimulation (mechanism: ?) |
| Gqα | ||
| αq, α11, α14 and α16 | Phospholipase Cβ1 through β4 | Stimulation |
| αq | Btk | Stimulation |
| G13α | ||
| α13 | p115-RhoGEF | Stimulation |
| PDZ-RhoGEF | Stimulation | |
| Leukemia-associated RhoGEF (LARG) | Stimulation | |
| α12 | Tec kinase tyrosine- phosphorylated LARG | Stimulation |
| Btk | Stimulation | |
| ras-GAP1m | Stimulation | |
a
For details see text.
b
Robert Margolskee, personal communication.