Table 2.

Elements of the coagulation homeostasis targeted as treatment for humans with septic shock. The only agent targeting coagulation homeostasis that has demonstrated a reduction in mortality to date is drotrecogin alfa (activated), which reduced 28-day all-cause mortality in patients with at least one organ dysfunction attributable to sepsis (Bernard et al 2001)

Platelets:

Platelet activating factor receptor antagonist

Platelet activating factor-acetylhydrolase

Protein C:

Drotrecogin alfa (activated) (Recombinant human activated protein C)

Tissue factor

Tifacogin (recombinant human tissue factor pathway inhibitor)

Antithrombin III

High dose antithrombin III