Table 1.
Prognostic value of CRP in primary prevention
| Study | n | Endpoint | Cutoff | Risk estimates |
|---|---|---|---|---|
| Ridker, Rifai, et al 2000 | 28 | Death/MI/stroke/revasc | >8.5 mg/L vs <0.6 mg/L | RR=1.5 |
| 263 | ||||
| Harris et al 1999 | 1293 | Death | ≥2.78 mg/L | RR=1.6 |
| Ridker et al 1997 | 543 | MI | ≥2.11 mg/L vs ≤0.55 mg/L | RR=2.9 |
| Ischemic stroke | ≥2.11 mg/L vs ≤0.55 mg/L | RR=1.9 | ||
| Tracy et al 1997 | 5201 | MI | >2.79 mg/L vs <0.97 mg/L | RR=2.67 |
| Ridker, Hennekens, et al 1998 | 122 | Death/MI/stroke/revasc | >7.3 mg/L vs <1.5 mg/L | RR=4.8 |
| MI/stroke | >7.3 mg/L vs <1.5 mg/L | RR=7.3 | ||
| Ridker, Glynn, et al 1998 | 144 | PAD | 2.1 mg/L vs 0.55 mg/L | RR=2.1 |
| Koeing et al 1999 | 936 | CV Death/MI | 6.6 mg/L vs 0.4 mg/L | RR=2.4 |
| Danesh et al 2000 | 1531 | CHD | >2.4 mg/L vs <0.9 mg/L | RR=2.13 |
| Mendall et al 2000 | 1395 | CHD | <0.83 mg/L vs >3.87 mg/L | p=ns |
| CV Death | p=ns | |||
| All cause mortality | p=0.0033 | |||
| Danesh et al 2004 | 6428 | CHD | >2.0 mg/L vs <0.78 mg/L | RR=1.45 |
Abbreviations: CHD, coronary artery disease; CRP, C-reactive protein; CV Death, fatal acute myocardial infarction or sudden death; MI, myocardial infarction; Revasc, revascularization; RR, relative risk; PAD, peripheral arterial disease.