Table 2.

Mean reduction from baseline in cuff and ambulatory blood pressure (mmHg) after 8 weeks of treatment with angiotensin II receptor blockers in two multicenter, double-blind trails. In the Oparil et al (2001) trial, the mean cuff dystolic blood pressure (DBP) and systolic blood pressure (SBP) values at baseline were 104 mmHg and 155–C157 mmHg. In the Brunner et al (2003) study, the mean ambulatory daytime DBP and SBP were ≈95 mmHg and ≈149 mmHg at baseline

	Oparil et al 2001				Brunner et al 2003
	Olmesartan medoxomil	Losartan	Valsartan	Irbesartan	Olmesartan medoxomil	Candesartan cilexetil
	20 mg (n=145)	50 mg (n=146)	80 mg (n=142)	150 mg (n=145)	20 mg (n=312)	8 mg (n=323)
Cuff measurements
DBPa	11.5	8.2***	7.9***	9.9*	15.8	15.1
SBP	11.3	9.5	8.4	11.0	21.2	21.1
Ambulatory measurements
24 h
DBP	8.5	6.2*	5.6*	7.4*	9.1	7.7*
SBP	12.5	9.0*	8.1*	11.3	12.7	11.0
Day
DBPb	10.2	7.2**	7.0***	8.8	9.3	7.8*
SBP	14.7	10.9**	10.2**	13.8	13.0	11.1*
Night
DBP	6.8	5.2	4.2**	5.9	7.9	6.7
SBP	10.3	7.3*	6.1**	8.8	10.9	9.7

^aNote: Primary endpoint in the trial by Oparil et al (2001);

^bPrimary endpoint in the trial by Brunner et al (2003);

^*p≤0.05;

^**p≤0.005;

^***p≤0.0005 vs olmesartan medoxomil.