Table 1.
Cardiovascular actions of Ang-(1–7)
| Ang-(1–7) — effect | Model | Study |
|---|---|---|
| Amplification of vasodilation mediated by bradykinin | Conscious rats | (Paula et al 1995) |
| Reduction of NE-release acting through a BK/NO-mediated mechanism stimulating cGMP/PKG-signaling | Hypertensive rat | (Gironacci et al 2004) |
| Coronary vasodilation mediated by NO | Canine coronary arteries in vitro | (Brosnihan et al 1996) |
| Release of vasodilator prostaglandins | Sprague-Dawley rats | (Benter et al 1993) |
| Reduction in plasma vasopressin concentration, blood pressure reduction | Hypertensive rats | (Benter et al 1995b) |
| Active vasodilation | Isolated rabbit afferent arterioles | (Ren et al 2002) |
| Bradykinin potentiation | Arterioles hypertensive rats in vivo | (Fernandes et al 2001) |
| Release of NO by Ang-(1–7) | Porcine coronary endothelium | (Porsti et al 1994) |
| Stimulation and release of vasodilator prostaglandins | Porcine aortic endothelial cells | (Jaiswal et al 1992) |
| Induction of bradykinin-mediated hypotensive responses | Anesthetized rat | (Abbas et al 1997) |
| Augmentation of bradykinin-induced vasodilation | Canine coronary artery rings | (Li et al 1997) |
| Endothelium-dependent relaxation | Canine middle cerebral artery | (Feterik et al 2000) |
| Cerebral vasodilation mediated by prostaglandins | Piglet pial arterioles | (Meng and Busija 1993) |
| Vasodilation mediated by EDRF | Feline mesenteric vascular bed | (Osei et al 1993) |
| Relaxation potentiated by losartan | Rat aorta | (le Tran and Forster 1997) |
| Vasodilation in the cutaneous and implant vasculature | Newly formed vasculatures (sponge implants) | (Machado et al 2002) |
| Bradykinin-induced vasodilation by Ang-(1–7) | Anestethized Wistar Rats | (Oliveira et al 1999) |
| Unmasking of a bradykinin mediated potentiation of ACE-inhibitors | Spontaneously hypertensive rats | (Fernandes et al 2001) |
Abbreviations: See Figure 1.