Table 2.
Biological actions of Ang-(1–7)
| Organ or system | Biological action | Reference |
|---|---|---|
| Cellular actions | • Stimulation of release of PGE2 and 6-keto-PGF1α | (Trachte et al 1990; Jaiswal et al 1992, 1993a, b; Benter et al 1995b) |
| • Augmentation of the vasodilator action of bradykinin | (Porsti et al 1994; Santos et al 1994; Paula et al 1995; Abbas et al 1997; Li et al 1997; Lima et al 1997) | |
| • Increased release of NO | (Osei et al 1993; Brosnihan et al 1996; Abbas et al 1997; Li et al 1997) | |
| • Antiproliferative actions in vascular smooth muscle | (Freeman et al 1996) | |
| Brain | • Stimulation of vasopressin release | (Schiavone et al 1988; Baracho et al 1995; Santos et al 1996) |
| • Facilitation of baroreflexes | (Campagnole-Santos et al 1989; Campagnole-Santos et al 1992; Silva et al 1993) | |
| Blood vessels | • Vasodilation and antihypertensive actions | (Benter et al 1993, 1995a, b) |
| Kidney | • Diuresis and natriuresis | (DelliPizzi et al 1994; Handa et al 1996; Andreatta-van Leyen et al 1993; Hilchey and Bell-Quilley 1995) |
| • Inhibition of tubular sodium and bicarbonate transport | (Handa et al 1994, 1996) |
Abbreviations: See Figure 1.