Table 2.
Prognostic Factors for Recurrence-Free Survival
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75% Recurrence-Free Survival
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Univariate Analysis (p Value)
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Multivariate Analysis (p Value)
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Variable | Group | No. Patients (%) | % Recurrences from Total Cases | 30 m | 60 m | 120 m | 30 m | 60 m | 120 m | 30 m | 60 m | 120 m |
Chromosome 1p36 | Diploid | 92 (62) | 3 | NR | NR | NR | 0.008 | 0.009 | 0.01 | 0.06 | 0.05 | 0.05 |
Losses | 32 (23) | 18 | NR | NR | 84 m | |||||||
Gains | 22 (15) | 0 | NR | NR | 97 m | |||||||
Chromosome 1q | Diploid | 108 (73) | 6 | NR | NR | NR | 0.9 | 0.8 | 0.8 | |||
Losses | 1 (1) | 0 | NR | NR | NR | |||||||
Gains | 39 (26) | 5 | NR | NR | NR | |||||||
Chromosome 7 | Diploid | 97 (73) | 6 | NR | NR | 98 m | 0.7 | 0.4 | 0.6 | |||
Losses | 0 (0) | 0 | NR | NR | NR | |||||||
Gains | 36 (27) | 8 | NR | NR | NR | |||||||
Chromosome 9 | Diploid | 107 (72) | 6 | NR | NR | NR | 0.01 | 0.8 | 0.07 | 0.7 | 0.3 | 0.4 |
Losses | 2 (1) | 50 | 12 m | 12 m | 12 m | |||||||
Gains | 40 (27) | 5 | NR | NR | 97 m | |||||||
Chromosome 10 | Diploid | 104 (70) | 6 | NR | NR | NR | <0.0001 | 0.0001 | 0.0002 | 0.05 | 0.004 | 0.01 |
Losses | 5 (3) | 60 | 23 m | 23 m | 23 m | |||||||
Gains | 39 (27) | 0 | NR | NR | 97 m | |||||||
Chromosome 11 | Diploid | 42 (76) | 7 | NR | NR | NR | 0.3 | 0.6 | 0.2 | |||
Losses | 0 (0) | 0 | NR | NR | NR | |||||||
Gains | 13 (24) | 15 | NR | NR | 97 m | |||||||
Chromosome 14 | Diploid | 97 (65) | 3 | NR | NR | NR | 0.001 | 0.03 | 0.04 | 0.06 | 0.5 | 0.4 |
Losses | 19 (13) | 26 | 29 m | 29 m | 29 m | |||||||
Gains | 32 (22) | 3 | NR | NR | 97 m | |||||||
Chromosome 15 | Diploid | 106 (71) | 6 | NR | NR | NR | 0.8 | 0.6 | 0.6 | |||
Losses | 0 (0) | 0 | NR | NR | NR | |||||||
Gains | 43 (29) | 7 | NR | NR | 97 m | |||||||
Chromosome 17 | Diploid | 106 (71) | 7 | NR | NR | NR | 0.8 | 0.9 | 0.7 | |||
Losses | 1 (1) | 0 | NR | NR | NR | |||||||
Gains | 42 (28) | 5 | NR | NR | 97 m | |||||||
Chromosome 18 | Diploid | 66 (67) | 6 | NR | NR | 84 m | 0.005 | 0.06 | 0.08 | 0.05 | 0.9 | 0.8 |
Losses | 5 (5) | 40 | 23 m | 23 m | 29 m | |||||||
Gains | 28 (28) | 0 | NR | NR | NR | |||||||
Chromosome 22 | Diploid | 59 (40) | 5 | NR | NR | 98 m | 0.6 | 0.7 | 0.8 | |||
Losses | 82 (55) | 6 | NR | NR | NR | |||||||
Gains | 8 (5) | 13 | 29 m | 29 m | NR | |||||||
Chromosome X | Diploid | 103 (70) | 7 | NR | NR | NR | 0.7 | 0.7 | 0.9 | |||
Losses | 17 (12) | 6 | NR | NR | 97 m | |||||||
Gains | 27 (18) | 4 | NR | NR | NR | |||||||
Chromosome Y | Diploid | 26 (58) | 9 | NR | NR | 84 m | 0.9 | 0.7 | 0.8 | |||
Losses | 9 (20) | 12 | NR | NR | NR | |||||||
Gains | 10 (22) | 11 | NR | 38 m | 38 m | |||||||
No. of tumor cell clones | 1 clone | 67 (45) | 4 | NR | NR | NR | 0.3 | 0.5 | 0.6 | |||
⩾2 clones | 82 (55) | 8 | NR | NR | 97 m | |||||||
Karyotype of the ancestral tumor cell clone | Diploid | 50 (36) | 0 | NR | NR | NR | <0.0001 | 0.0003 | <0.0001 | 0.001 | 0.04 | 0.02 |
−22 | 42 (28) | 0 | NR | NR | NR | |||||||
−1p/−14q | 11 (7) | 46 | 23 m | 24 m | 24 m | |||||||
Chromosome losses other than −22 and −1p/−14q | 28 (18) | 7 | NR | NR | NR | |||||||
Chromosome gains | 18 (11) | 11 | NR | NR | NR |
Abbreviations: NR, not reached; m, months.