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. 2007 Oct;9(4):438–446. doi: 10.1215/15228517-2007-026

Table 3.

Prognostic impact of the clinicobiological characteristics of histologically benign/grade I meningiomas on early recurrence-free survival (n = 149)

Prognostic Factors for Recurrence-Free Survival
75% Recurrence-Free Survival
Univariate Analysis (p Value)
Multivariate Analysis (p Value)
Variable Group No. Patients (%) % Recurrences from Total Cases 30 m 60 m 120 m 30 m 60 m 120 m 30 m 60 m 120 m
Age (years) <55 47 (32) 11 NR NR 66 m 0.1 0.02 0.002 0.008 0.001
⩾55 102 (68) 4 NR NR NR
Sex Male 43 (29) 14 NR NR 31 m 0.01 0.08 0.05 0.4 0.2 0.6
Female 106 (71) 3 NR NR NR
Tumor location Convexity 36 (24) 8 NR NR 97 m 0.05 0.2 0.1 0.5 0.7 0.9
Parasagittal or tentorial 44 (29) 9 NR NR NR
Ventricular 3 (2) 43 23 m 23 m 23 m
Cranial base 51 (34) 2 NR NR 41 m
Spinal 15 (10) 0 NR NR NR
Histologic subtype Meningotheliomatous 107 (78) 9 NR NR NR 0.2 0.2 0.3
Psammomatous 17 (12) 0 NR NR NR
Transitional 13 (9) 0 NR NR NR
Fibroblastic 2 (1) 0
Tumor size <30 mm 36 (24) 6 NR NR NR <0.0001 0.004 0.003 0.008 0.01 0.003
30–50 mm 64 (43) 10 NR NR 98 m
>50 mm 49 (33) 25 NR NR 97 m
Simpson’s grade 1 6 (4) 17 NR NR NR 0.4 0.7 0.3
2 52 (35) 4 NR NR NR
3 91 (61) 7 NR NR 97 m
DNA ploidy status DNA diploid 126 (84) 5 NR NR NR 0.4 0.9 0.6
DNA aneuploid 23 (16) 9 NR NR 84 m
% S phase + G2M tumor cells ⩽1 43 (29) 2 NR NR NR 0.8 0.8 0.8
>1 106 (71) 5 NR NR 97 m

Abbreviations: NR, not reached; m, months.