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. Author manuscript; available in PMC: 2008 Jul 15.
Published in final edited form as: Cardiovasc Res. 2007 Mar 12;75(2):381–389. doi: 10.1016/j.cardiores.2007.03.004

5. Endogenously derived NO stimulates HO-1 promoter activity in vascular SMC.

5

A. NO synthesis following treatment of SMC with a cytokine mixture (CM) consisting of interleukin-1β (10 ng/ml), tumor necrosis factor-α (20 ng/ml), or interferon-γ (200 U/ml) for 24 hours in the presence or absence of methyl-L-arginine (L-NMA; 1 mM). B. HO-1 promoter activity following treatment of SMC with the CM for 24 hours in the presence and absence of L-NMA (1 mM). Results are expressed as the means ± SEM of 6 separate experiments. *Statistically significant increase in NO synthesis or HO-1 promoter activity.