Fig. 1.

Plasma glucose and exhaled methyl nitrate profiles in 18 experiments performed in 10 children with T1DM. Children started experiments in either hyperglycemic or euglycemic conditions; if hyperglycemic, euglycemia was gradually restored by i.v. insulin infusion; if euglycemic, euglycemia was maintained for the duration of the study. In 16 of 18 experiments, exhaled methyl nitrate profiles closely paralleled plasma glucose. The left y axis shows blood glucose levels in milligrams per deciliter, the right y axis is exhaled (Δ) methyl nitrate in pptv, and the x axis is time in hours. Each subject is denoted by a letter, and multiple visits by a single subject are denoted by a subscripted number following the letter.