Figure 5.

Effect of tranexamic acid (TXA) treatment on leukocyte recruitment to the lungs of C57BL/6 Plg^+/+ and Plg^−/− mice. (A) Total leukocyte counts in the bronchoalveolar lavage fluid of Plg^+/+ (open bars) and Plg^−/− (solid bar) mice after phosphate-buffered saline (PBS) or ovalbumin (OVA) treatment. Wild-type mice treated with OVA/TXA had reduced total leukocyte recruitment compared with those that received only OVA. The inhibition was to the level of cells present in the BAL of PBS-treated controls. TXA caused no additional reduction in leukocytes in Plg^−/− mice. (B) Differential cell counts in BAL fluid showed that TXA (Solid bars) treatment significantly reduced lymphocyte and eosinophil recruitment while the number of macrophages remained the same as in mice treated only with OVA (open bars). Values are expressed as mean ± SEM; n = 3–9 mice/group.