Figure 6.

Effects of tranexamic acid (TXA) treatment on lung histology in ovalbumin (OVA)-treated Plg^+/+ C57BL/6 mice 3 hours after challenge on Day 21. Representative photomicrographs of hematoxylin-and-eosin (A and C)– and Masson trichrome (B and D)–stained lung sections are shown (original magnification, ×100); n = 3–9 mice/group. TXA treatment reduced leukocytosis in the perivascular and peribronchial areas (C) compared with wild-type mice that received only OVA (A). TXA also reduced collagen deposition in the subepithelial areas (D) compared with treatment with OVA alone (B). Bars = 137 μm.