TABLE 4.
PULMONARY FUNCTION TESTING AND EXERCISE DATA AT BASELINE AND 6 MONTHS POSTRANDOMIZATION TO TREATMENT
| Baseline
|
6 mo
|
|||||
|---|---|---|---|---|---|---|
| Med (n = 27) | LVRS (n = 28) | p | Med (n = 27) | LVRS (n = 28) | p | |
| FEV1, % | 28.2 ± 6.6 | 25.7 ± 6.9 | 0.18 | 26.4 ± 6.5 | 34.3 ± 9.9* | 0.001 |
| TLC, % | 121.4 ± 8.1 | 123.0 ± 14.8 | 0.63 | 123.8 ± 10.5 | 107.7 ± 15.0* | < 0.001 |
| RV, % | 203.1 ± 28.6 | 222.2 ± 55.3 | 0.11 | 216.2 ± 39.7 | 165.1 ± 38.6* | < 0.001 |
| DlCO, % | 30.1 ± 8.1 (n = 27) | 28.0 ± 11.3 (n = 28) | 0.44 | 29.7 ± 8.9 (n = 22)† | 31.2 ± 12.0 (n = 25)† | 0.65 |
| PaO2, mm Hg | 64.4 ± 8.7 | 65.5 ± 12.6 | 0.70 | 64.11 ± 9.7 | 73.8 ± 11.7* | 0.002 |
| PaCO2, mm Hg | 44.6 ± 5.0 | 43.9 ± 6.3 | 0.65 | 46.0 ± 5.8 | 40.3 ± 4.6* | < 0.001 |
| 6MWD, ft | 1,252 ± 352 (n = 27) | 1,238 ± 300 | 0.87 | 1,203 ± 358 (n = 25) | 1,313 ± 313 | 0.24 |
| Max watts | 49.4 ± 23.9 (n = 27) | 42.8 ± 26.6 (n = 28) | 0.33 | 44.5 ± 27.9 (n = 26) | 49.9 ± 22.5 (n = 26) | 0.45 |
Definition of abbreviations: DlCO = diffusing capacity of carbon monoxide; Max watts = maximum wattage on cardiopulmonary exercise testing; Med = medical (treatment group); 6MWD = six-minute-walk distance; RV = residual volume.
*
p < 0.05 compared with baseline measurement.
†
Performed at 12 mo.