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Time course of Fas-induced activation of extracellular signal–regulated kinase (ERK)1/2 (as illustrated by the increase in the ratio of phosphorylated to total ERK) in (A) MLE 12 cells and (B) LA-4 cells after exposure to Jo2 antibody (50 ng/ml). n = 4 per group. Statistical analysis involved one-way ANOVA followed by the Student-Newman-Keuls test. * P< 0.05 versus 0 minutes, #P < 0.05 versus 60 minutes, +P < 0.05 versus PD 98059.
