Figure 1.

Changes in pulmonary resistance (Rl) induced by intravenous methacholine in ovalbumin (OVA)-sensitized wild-type (C57BL/6) and ob/ob mice challenged with aerosols of either phosphate-buffered saline (PBS) or OVA once per day for 7 consecutive days. Responses were measured 24 hours after the cessation of the final aerosol challenge. n = 9–10 mice for each group. Solid circles, wild-type (PBS); solid squares, wild-type (OVA); open circles, ob/ob (PBS); open squares, ob/ob (OVA). *P < 0.05 compared with wild-type (C57BL/6) mice with an identical exposure; ^#P < 0.05 compared with genotype-matched, PBS-challenged controls.