Figure 4.

(A–D) Representative hematoxylin-and-eosin–stained histologic sections, (E) inflammation score, and (F) periodic acid-Schiff (PAS) reaction prevalence of carbohydrates and mucoproteins from the lungs of ovalbumin (OVA)-sensitized wild-type (C57BL/6) and ob/ob mice challenged with aerosols of either phosphate-buffered saline (PBS) or OVA once per day for 7 consecutive days. A and B are sections from PBS-challenged wild-type and ob/ob mice, respectively. C and D are sections from OVA-challenged wild-type and ob/ob mice, respectively. Lungs were fixed in situ with 10% formalin 24 hours after the cessation of the final aerosol challenge. n = 6–7 mice for each group. Solid bars, wild-type; open bars, ob/ob. *P < 0.05 compared with genotype-matched, PBS-challenged controls; ^#P < 0.05 compared with wild-type (C57BL/6) mice with an identical exposure.