Figure 8.

Changes in (A) pulmonary resistance (Rl) and (B) dynamic compliance (Cdyn) induced by intravenous methacholine in ovalbumin (OVA)-sensitized wild-type (C57BL/6) and db/db mice challenged with aerosols of either phosphate-buffered saline (PBS) or OVA once per day for 3 consecutive days. Responses were measured 48 hours after the cessation of the final aerosol challenge. n = 6–7 mice for each group. Solid circles, wild-type (PBS); solid squares, wild-type (OVA); open circles, db/db (PBS); open squares, db/db (OVA). *P < 0.05 compared with wild-type (C57BL/6) mice with an identical exposure; ^#P < 0.05 compared with genotype-matched, PBS-challenged controls.