Table 4 Clinical and laboratory data and molecular expression in the muscle tissue before and after the first and third intravenous immunoglobulin infusion.
| Markers | Before treatment (n = 13) | 24–48 h after first infusion (n = 10) | 1–2 weeks after third infusion (n = 9) |
|---|---|---|---|
| FI scores† | 37.0 (16.5–57.5) | NA | 49.0 (22.0–59.0)* |
| CK levels‡ | 5.30 (0.30–58.4) μcat/l | NA | 2.80 (0.5–24.0) μcat/l |
| CD 3 | 9.01 (1.35–190) cells/mm2 | 9.68 (1.49–143) cells/mm2 | 10.4 (1.25–104) cells/mm2 |
| CD163 | 0.29 (0.01–3.16)% | 0.61 (0.03–1.78)% | 0.26 (0.10–0.99)% |
| CD163 | 88.9 (2.30–392) cells/mm2 | 98.9 (14.1–483) cells/mm2 | 82.4 (24.0–174) cells/mm2 |
| MHC‐I§ | 3.77 (1.01–37.3)% | 8.8 (0.54–46.3)% | 3.01 (1.17–46.7)% |
| ICAM‐1§ | 0.30 (0.13–1.33)% | 0.26 (0.14–0.71)% | 0.25 (0.11–0.58)% |
| ICAM‐1 | 7.47 (0.00–46.5) cap/mm2 | 11.8 (5.87–36.1) cap/mm2 | 10.9 (2.49–70.1) cap/mm2 |
| VCAM‐1 | 3.96 (0.00–6.31) cap/mm2 | 1.17 (0.19–11.1) cap/mm2 | 0.92 (0.31–5.74) cap/mm2 |
| IL1α§ | 0.09 (0.02–0.40)% | NA | 0.11 (0.01–0.39)% |
| IL1α | 16.1 (2.50–153) cells/mm2 | NA | 21.4 (1.88–36.3) cells/mm2 |
| IL1α | 26.7 (5.27–57.2) cap/mm2 | NA | 25.3 (7.89–80.5) cap/mm2 |
| IL1α | 4.16 (0.00–10.5) l.v./mm2 | NA | 4.87 (0.00–14.6) l.v./mm2 |
Cap, capillaries; CD, cluster of differentiation; FI, Functional Index in Myositis; ICAM‐1, intercellular adhesion molecule‐1; IL, interleukin; l.v., large vessels; MHC, major histocompatibility complex; NA, not assessed; VCAM‐1, vascular cell adhesion molecule‐1.
Results are shown as median (range).
*p Value = 0.012.
†Maximum FI scores = 64, FI scores from the right side and the left side correlated very well (r = 0.968, p<0.0001), thus the mean value was assessed for the analysis.
‡CK reference levels <2.5 μcat/l.
§Percentage MHC‐I, ICAM‐1 and IL1α include expression in inflammatory cells, capillaries, blood vessels and fibres.