Table 5 Manual evaluation of major histocompatibility complex class I antigen expression on the surface of muscle fibres, and membranolytic attack complex deposits in capillaries and in necrotic muscle fibres, and on the surface of non‐necrotic fibres.
Patients/diagnosis | MHC class I antigen | MAC | |||||||
---|---|---|---|---|---|---|---|---|---|
Fibres | Capillaries | Fibres | |||||||
B.T. | After 24–48 h | After third inf | B.T. | After 24–48 h | After third inf | B.T. | After 24–48 h | After third inf | |
1/PM | + | – | + | + | + | ++ | + | – | – |
2/PM | ++++ | + | ++ | + | + | + | ++ | ++ | + |
3/PM | + | + | + | ++ | ++ | + | +++ | +++ | + |
4/PM | +++++ | +++++ | NA | ++ | +++ | NA | + | + | NA |
5/PM | ++++ | ++++ | NA | ++ | + | NA | +++ | + | NA |
6/PM | – | + | + | ++ | ++ | +++ | – | – | + |
7/DM | + | + | + | + | + | + | +++ | ++ | + |
8/DM | +++++ | ++++ | NA | +++ | ++ | NA | – | + | NA |
9/DM | +++ | +++++ | NA | ++ | ++ | NA | ++ | + | NA |
10/DM | + | NA | + | + | NA | ++ | – | NA | ++ |
11/JDM | + | NA | + | + | NA | + | – | NA | – |
12/IBM | +++++ | NA | +++++ | + | NA | + | ++ | NA | ++ |
13/IBM | + | +++ | +++++ | ++ | +++ | +++ | + | – | – |
B.T., before treatment; DM, dermatomyositis; IBM, inclusion body myositis; Inf, infusion; JDM, juvenile onset dermatomyositis; NA, not available/assessable; PM, polymyositis.
Grading explanations are described in table 3. Individual changes after the third infusion: in major histocompatibility complex‐I, ⇔ 1–3, 6–7, 10–12 ⇑ 13; in membranolytic attack complex fibres, ⇔ 1–2, 6, 11–13 ⇓ 3, 7 ⇑ 10; in membranolytic attack complex capillaries, ⇔ all patients.