Figure 7 c‐Jun (NH2) terminal kinase (JNK) inhibition does not affect the synthesis of paracetamol–protein adducts, but markedly inhibits the production of tumour necrosis factor α (TNFα) in the liver after paracetamol‐induced hepatic injury. Mice were injected intraperitoneally with control, SP600125 (30 mg/kg) or d‐JNKI1 (c‐jun N‐terminal kinase peptide inhibitor 1, d‐stereoisomer; 30 μg/mouse) 1 h before paracetamol administration (350 mg/kg; n = 6 mice in each group). (A) Anti‐paracetamol–protein adduct staining in normal, untreated mouse liver. Scale bar 200 μm. (B–D) Formation of anti‐paracetamol–protein adduct 5 h after paracetamol administration. (E) Time course of hepatic interferon γ (IFNγ) production after paracetamol administration (p = NS). (F) Time course of hepatic TNFα production after paracetamol administration (*p<0.05).