Table 2 Risk of adenocarcinoma for serum pepsinogen I:II <2.5 (relative to serum pepsinogen I:II >2.5) and serum gastrin concentration ⩾60 ng/l (relative to serum gastrin concentration <60 ng/l) according to gastric subsites and Helicobacter pylori serostatus.

Gastric subsite	H pylori serostatus
Risk factor	Overall	Seropositive	Seronegative
Non‐cardia	129 cases, 376 controls	116 cases, 247 controls	13 cases, 129 controls
Pepsinogen I:II >2.5	1.00 (reference)	1.00 (reference)	1.00 (reference)
Pepsinogen I:II <2.5	4.47 (2.71 to 7.37)	3.45 (2.01 to 5.91)	12.6 (2.25 to 70.7)*
p Value	<0.001	<0.001	0.004
Gastrin <60 ng/l	1.00 (reference)	1.00 (reference)	1.00 (reference)
Gastrin ⩾60 ng/l	3.18 (2.03 to 4.99)	2.77 (1.69 to 4.54)	3.05 (0.71 to 13.1)
p Value	<0.001	<0.001	0.133
Cardia	44 cases, 132 controls	19 cases, 93 controls	25 cases, 39 controls
Pepsinogen I:II >2.5	1.00 (reference)	1.00 (reference)	1.00 (reference)
Pepsinogen I:II <2.5	1.60 (0.62 to 4.14)	3.33 (1.06 to 10.5)	†
p Value	0.333	0.039
Gastrin <60 ng/l	1.00 (reference)	1.00 (reference)	1.00 (reference)
Gastrin ⩾60 ng/l	0.88 (0.37 to 2.06)	2.23 (0.63 to 7.87)	0.38 (0.05 to 3.03)
p Value	0.761	0.213	0.362

Risk of adenocarcinoma estimated by OR with associated 95% CI in an unconditional logistic regression model with adjustment for the matching variables in the original study design.

*Unconditional logistic regression analysis without adjustment for the matching variables (only three cases with pepsinogen I:II <2.5 precluded adjustment).

†There were no H pylori seronegative cardia cases or controls with pepsinogen I:II <2.5.