Table 3 Risk of adenocarcinoma for serum pepsinogen I:II <2.5 (relative to serum pepsinogen I:II >2.5) and serum gastrin concentration ⩾60 ng/l (relative to serum gastrin concentration <60 ng/l) according to gastric subsites and adenocarcinoma subtypes.

Gastric subsite	Histology
risk factor	Overall*	Intestinal	Diffuse	Mixed
Non‐cardia	129 cases, 376 controls	59 cases, 173 controls	35 cases, 100 controls	31 cases, 91 controls
Pepsinogen I:II >2.5	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Pepsinogen I:II <2.5	4.32 (2.58 to 7.24)	6.68 (2.79 to 16.0)	3.21 (1.27 to 8.13)	2.32 (0.86 to 6.25)
p Value	<0.001	<0.001	0.014	0.097
Gastrin <60 ng/l	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Gastrin ⩾60 ng/l	2.97 (1.92 to 4.61)	4.04 (2.05 to 7.96)	2.11 (0.92 to 4.86)	2.40 (1.06 to 5.44)
p Value	<0.001	<0.001	0.079	0.036
Cardia	44 cases, 132 controls	31 cases, 93 controls	7 cases, 21 controls	5 cases, 15 controls
Pepsinogen I:II >2.5	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Pepsinogen I:II <2.5	1.56 (0.60 to 4.09)	0.72 (0.19 to 2.79)	3.46 (0.32 to 37.5)	—
p Value	0.365	0.632	0.307
Gastrin <60 ng/l	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Gastrin ⩾60 ng/l	0.85 (0.38 to 1.88)	0.59 (0.22 to 1.58)	5.30 (0.52 to 54.6)	0.69 (0.06 to 8.04)
p Value	0.689	0.295	0.161	0.764

Risk of adenocarcinoma estimated by OR with associated 95% CI.

*Including four histologically unclassifiable cases and 12 corresponding controls.

– not applicable.