Table 2 Comparison of histological findings of cuffed femoral artery segments from 14‐day control DEC, SEC and PEC (14 days normal cuff plus 14 days DEC).

	TUNEL+ cells (%)		SMC content (%)			Collagen content (%)
	Media	Intima	Media	Intima	Media		Intima	IEL disruption¶	Medial macrophage¶
Control DEC	0.27 (0.24)	0.39 (0.24)	25.2 (2.3)	30.8 (2.7)	28.3 (4.9)		40.7 (2.4)	2.2 (0.6)	1.08 (0.08)
1% SEC	1.99 (0.68)	0.58 (0.24)	27.5 (2.7)	28.0 (1.1)	24.0 (3.4)		28.0 (5.8)	2.0 (0.5)	1.39 (0.15)
2.5% SEC	1.78 (0.77)	0.42 (0.21)	16.9 (2.9)*†	21.8 (2.8)	24.0 (3.1)		32.9 (4.9)	2.2 (0.5)	1.49 (0.16)*
1% PEC	0.84 (0.79)	0.95 (0.56)	2.6 (0.9)*†‡	10.3 (1.7)*†‡	18.6 (1.4)		19.0 (2.1)*‡	3.4 (0.4)	2.20 (0.39)*
2.5% PEC	19.2 (5.7)*†‡§	3.1 (3.08)	3.8 (0.9)*†‡	9.4 (3.1)*†‡	12.7 (2.0)*†‡		12.4 (6.4)*‡	5.2 (0.6)*†‡§	2.26 (0.33)*

Values are mean (SEM); n = 8/group.

DEC, drug‐eluting cuff; IEL, internal elastic lamina; PEC, paclitaxel‐eluting cuff; SEC; sirolimus‐eluting cuff; SMC, smooth muscle cell.

*p<0.05 vs control DEC; †p<0.05 vs 1% SEC; ‡p<0.05 vs 2.5% SEC; §p<0.05 vs 1% PEC.

¶IEL disruption was quantified as the number of broken IEL for each cuffed artery segment; medial macrophage content was assessed with a 1–3 score.