Figure 1 Histology of budding (A) and dedifferentiation (B). Budding was defined as ⩾10 budding foci, where each focus was composed of an isolated cell or a small cluster of fewer than five cancer cells in the invasive front. Dedifferentiation was defined as solid trabecular nests of cancer cells (five or more cells in each nest) at the invasive front. (A: H&E, ×200; B: H&E, ×100.)