Table 2 Histopathological criteria to distinguish prostatic lesions with ductal morphology.

Morphological criteria	PIN	Intraductal carcinoma	Ductal carcinoma
Size of glands/ducts	Normal—distended	Markedly distended	Large duct‐like structures
Lumen spanning	Occasional	Required	Yes
Basal cells	Yes	Yes, disrupted	Rarely
Columnar	No	Occasionally	Yes
Papillary structures	No	No	Occasionally
Cribriform pattern	Yes	Frequently	Frequently
Central necrosis	No	Occasionally	Occasionally
Severe nuclear atypia	Rare	Occasionally	Occasionally
Maturation effect	Yes	Occasionally	No
Stromal haemosiderin	No	No	Occasionally

PIN, prostatic intraepithelial neoplasm.