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Targeting the mouse RORα locus. (A) Schematic representation of the wild-type RORα locus, targeting vector, and recombined locus. In the targeted locus the exon of the second zinc finger of the DNA binding domain (filled box) is disrupted and fused to lacZ encoding β-gal. (B) Diagnostic Southern blot hybridization was performed by using the probe indicated in A. Lanes are homozygous (−/−), heterozygous (+/−), and wild-type (+/+) DNA.
