Figure 2.

Comparison of physical performance of RORα^−/− and staggerer mice in the motor synchronization learning (rotarod) test. (A) Duration the mice stayed on the rotarod. Wild-type (+/+) (n = 10) and heterozygous RORα knockout mice (+/−) (n = 10) managed to stay on the rod for the entire 180 sec; homozygous RORα knockout mice (−/−) and sg/sg mice never reached this maximal score (n = 12). However, the RORα^−/− mice significantly improved from day 1 to day 10 (Mann–Whitney, P > 0.05), whereas the sg/sg mice did not at all. (B) Strategy used by mice to stay on the rod. Wild-type (n = 10) and RORα^+/− mice (n = 10) used exclusively walking, whereas RORα^−/− mice and sg/sg mice (n = 12) used principally or exclusively hanging, respectively.