Table 1 Immunohistochemical staining reactions in testicular neoplasms19,20,21,22,23,24,26,28,29,33,34,42,44,53,57,62,63,68,73,76,85,89,96,101,102,103,104,105,106.
| AE1/AE3 | Cam5.2 | PLAP | OCT4 | AFP | hCG | c‐kit | CD30 | Inh | Ch | PSA | V | S100 | De | Ca | LCA | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Seminoma (usual type) | v | v | + | + | – | – | + | – | – | – | – | v | – | N | – | – |
| Spermatocytic seminoma | – | v | – | – | – | – | v | – | N | N | N | – | – | – | N | – |
| Embryonal carcinoma | + | + | + | + | v | – | – | + | – | – | N | – | – | N | – | – |
| Yolk sac tumour | + | + | + | – | v | – | – | – | – | – | N | v | – | N | – | – |
| Choriocarcinoma | + | + | + | – | – | + | N | – | + | – | N | – | – | N | – | N |
| Carcinoid | v | + | – | – | N | N | – | – | – | + | – | v | v | N | v | N |
| IGCNU | – | – | + | + | – | – | + | – | – | – | N | N | – | N | N | – |
| Sertoli cell tumour | v | v | v | – | – | – | – | N | + | – | N | v | v | N | v | – |
| LCCSCT | – | v | – | – | – | – | – | N | + | N | N | + | + | + | N | N |
| Leydig cell tumour | v | v | – | – | – | – | N | N | + | – | N | + | v | – | + | N |
| Adult‐type GCT | v | v | N | – | N | N | N | N | + | N | N | + | v | + | + | N |
| Juvenile GCT | v | + | – | – | – | – | N | N | + | – | N | + | + | v | + | N |
| Adenomatoid tumour | + | + | – | – | – | – | N | N | – | – | N | + | N | N | + | N |
| Mesothelioma | + | + | – | – | – | – | – | v | – | v | – | + | – | – | + | N |
| Rhabdomyosarcoma | – | v | – | – | – | – | – | – | – | – | N | + | – | + | N | N |
| Lymphomas | – | – | – | – | – | – | – | v | – | – | N | v | – | – | – | + |
| Plasmacytoma | – | – | – | N | N | N | v | – | – | N | N | v | – | N | – | v |
| Metastatic prostatic carcinoma | + | + | – | – | N | N | v | N | N | v | + | – | – | N | – | N |
| Metastatic melanoma | – | – | – | – | – | N | v | – | – | – | – | + | + | – | N | – |
The data in this table are derived from the above references and personal observations.
IGCNU, intratubular germ cell neoplasia, unclassified type; LCCSCT, large cell calcifying Sertoli cell tumour; GCT, granulasa cell tumour; PLAP, placental alkaline phosphatase; AFP, α‐fetoprotein; hCG, human chorionic gonadotropin; Inh, inhibin‐α; Ch, chromogranin; PSA, prostate specific antigen; V, vimentin; De, desmin; Ca, calretinin; LCA, leucocyte common antigen; +, usually positive (>80% of cases); v, variable expression (20–80% of cases); −, usually negative (<20% of cases); N, no data available.