Figure 2 (A,B) Representative nuclei extracted from paraffin‐wax‐embedded tissue showing abnormal and normal signal patterns for MLL. The LSI MLL break‐apart probe is labelled with spectrum green at the 5′ centromeric MLL gene break‐apart region and with spectrum orange at the 3′ telomeric region. (A,B) Positive 11q23 rearrangement pattern of one green/one orange (yellow) fusion signal, one orange signal and one green signal (1O1G1F). (C,D) Negative pattern of two orange/green (yellow) fusion signals.