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. 2006 Jun 21;60(5):515–519. doi: 10.1136/jcp.2006.038711

graphic file with name cp38711.f2.jpg

Figure 2 (A) Normal bronchial epithelium is mostly negative for acid cysteine protease inhibitor (ACPI), with only weak expression is seen in the basal cells (arrow). (B) Normal bronchial epithelium adjacent to the dysplastic epithelium. Negative ACPI staining in the basal‐cell layer (arrow) and positive staining in the upper parts of the epithelium (star). The strongly stained dysplastic epithelium is seen in upper left. (C) Dysplastic bronchial epithelium showing strong staining of ACPI in upper two‐thirds of the epithelium (star). (D) Squamous‐cell carcinoma showing a positive staining for ACPI in the peripheral area of the tumour epithelium (arrow). (E) Strong staining for ACPI in adenocarcinoma. (F) Well‐differentiated squamous‐cell carcinoma with strong ACPI staining. Note the concentration of staining signal around the keratin pearls (arrow). Original magnification×330.