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. Author manuscript; available in PMC: 2008 Apr 23.
Published in final edited form as: Tetrahedron. 2007 Apr 23;63(17):3575–3584. doi: 10.1016/j.tet.2006.08.110

Figure 1.

Figure 1

(A) Proposed secondary structure of the 5′-leader sequence of the HIV-1 genomic RNA, with the DIS (SL1) stem-loop highlighted. [Boxed above] RNA sequence and secondary structure of the DIS (SL1) stem-loop found in the HIV-1 subtype-A isolate. The DIS loop contains a highly conserved hexanucleotide palindrome sequence and flanked by conserved purine nucleotides. Positions in the sequences which differ for the subtype-B isolate of HIV-1, a second major strain of the virus, are indicated by arrows and substituted nucleotides. [Boxed below] RNA sequence and secondary structure of the Ψ-site packaging sequence found in the HIV-1 subtype-A isolate.