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. Author manuscript; available in PMC: 2008 Jul 9.
Published in final edited form as: Vaccine. 2006 Nov 27;25(28):5126–5132. doi: 10.1016/j.vaccine.2006.11.024

Fig. 1.

Fig. 1

Effect of BCG vaccination on M. tuberculosis CNS infection and dissemination. A. Number of CFU of M. tuberculosis HN878 in the CSF. Control non-vaccinated rabbits (black squares) (n=12), rabbits vaccinated with BCG (open squares) (n=5). B. Number of CFU of M. tuberculosis H37Rv in the CSF. Control non-vaccinated rabbits (black triangles) (n=10), rabbits vaccinated with BCG (open triangles) (n=8). Bacillary clearance was significantly accelerated in BCG-vaccinated rabbits challenged with H37Rv compared to challenge with HN878 (*P=0.02). C. CFU in tissues 8 weeks post-infection with HN878. Control nonvaccinated rabbits (black bars) (n=7), BCG-vaccinated rabbits (white bars) (n=5). D. CFU in tissues 8 weeks post-infection with H37Rv. Control non-vaccinated rabbits (black bars) (n=10), BCG-vaccinated rabbits (white bars) (n=8). Significant differences in dissemination of H37Rv vs HN878 to the liver and spleen of BCG-vaccinated rabbits were observed (*P=0.01). Values are mean ± SEM.