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. 2007 Oct 1;117(10):2825–2833. doi: 10.1172/JCI32490

Figure 4. Studies of conditional Bnip3 overexpression in adult mice.

Figure 4

(A) Double conditional transgenesis strategy (see text for details). (B) Schematic of experimental design. (C) Echocardiographically determined LV end-diastolic diameter (left) and LV fractional shortening (right) before Bnip3 induction (week 8) and 2 weeks (week 10) and 12 weeks after induction (week 20); n = 10 pairs at 8 and 10 weeks and n = 5 pairs at 20 weeks. (D) TUNEL-derived apoptotic indices in infarcted mice. (E) Quantitative infarct size after 48 hours (n = 5–6/group). (F).Caspase-3 cleavage studies. (G) Triphenyltetrazolium chloride–stained cardiac cross-sections 48 hours after coronary occlusion. Original magnification, ×1. *P < 0.05 vs. controls.