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. Author manuscript; available in PMC: 2008 May 18.
Published in final edited form as: J Mol Biol. 2007 Mar 6;368(5):1392–1402. doi: 10.1016/j.jmb.2007.02.081

Figure 8.

Figure 8

Induced fit in RS2-1G9 (lactam complex in grey, ethylene glycol complex in green, stereoview). Upon ligand binding, the main-chain and side-chain atoms of CDR H3 undergo the largest rearrangements, while L3, L1, and H2 move to a minor extent. L2 and H1 are essentially not in contact to the hapten derivative and, hence, are not displayed. In particular, the tip of H3 completely reorganizes upon ligand binding to accommodate the lactam in the binding pocket (induced fit). For clarity, TyrH98, TyrH99, AsnH100, and AsnH100A are labeled in both structures.