. Author manuscript; available in PMC: 2008 Jan 1.

Published in final edited form as: J Hepatol. 2007 Feb 22;47(1):23–30. doi: 10.1016/j.jhep.2007.01.027

Table 2.

Predictive values of week 1 log₁₀ HCV RNA, the ratio between baseline and week 1 alanine aminotransferase levels, and the linear combination with the best discriminatory ability (ALT_d7/ALT_d0 + 0.7 log₁₀ HCV RNA).

	log₁₀HCV RNA	ALT_d7/ALT_d0	log₁₀HCV RNA_d7 - 0.67 ALT_d7/ALT_d0 + 0.01 RBV_d7.
Cutoff	≤ 5.5	≤ 0.7	≤ 4.7
PPV	60	71	67
NPV	100	93	100
Sn	100	83	100
Sp	75	87	81
AUROC ± SE	0.96 ± 0.03	0.80 ± 0.11	0.98 ± 0.02

Formulas and abbreviations: ALT_d7/ALT_d0, ratio of day 7 to baseline alanine aminotransferase levels; PPV, positive predictive value; NPV, negative predictive value; Sn, sensitivity; Sp, specificity; AUROC, area under the receiver operator characteristic curve; SE, standard error.