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. Author manuscript; available in PMC: 2008 Jul 2.
Published in final edited form as: Brain Res. 2007 Apr 22;1156:31–45. doi: 10.1016/j.brainres.2007.04.043

Table 1. Results of statistical analyses of dopamine receptor expression levels from E12 to P60.

Statistical analyses of developmental change in dopamine receptor mRNA expression. For each brain region changes in expression levels of the five receptors (D1R, D2R, D3R, D4R and D5R) during development (developmental interval indicated in parentheses for each region) was analyzed by ANOVA. Differences in the expression levels between specific developmental intervals were analyzed by Bonferroni test. NS = not significant, for ANOVA p>0.001 for Bonferroni p>0.05.

Striatum (E12-P60)
D1R D2R D3R D4R D5R
ANOVA (E12 to P60) F(dfbtw, dfw) p<0.0001 17.11 (4,53) p<0.0001 113.9 (4,53) NS p<0.0001 182.8 (4,52) p<0.0001 20.91 (4,52)
E12 vs E15 NS NS p< 0.001 NS
E12 vs P0 NS NS p< 0.001 NS
E12 vs P21 P< 0.001 p< 0.001 NS p< 0.001
E12 vs P60 P< 0.001 p< 0.001 NS p< 0.01
E15 vs P0 NS NS NS NS
E15 vs P21 P< 0.05 p< 0.001 p< 0.001 p< 0.001
E15 vs P60 NS p< 0.001 p< 0.001 p< 0.01
P0 vs P21 P< 0.001 p< 0.001 p< 0.001 p< 0.001
P0 vs P60 P< 0.001 p< 0.001 p< 0.001 p< 0.001
P21 vs P60 NS p< 0.01 NS p< 0.01
Globus Pallidus (P0–P60)
D1R D2R D3R D4R D5R
ANOVA (P0 to P21) F(dfbtw, dfw) NS NS p=0.0001 24.83 (2, 10) p<0.0001 73.07 (2, 10) NS
P0 vs P21 p< 0.01 p< 0.001
P0 vs P60 p< 0.001 p< 0.001
P21 vs P60 NS NS
Frontal cortex (E15-P60)
D1R D2R D3R D4R D5R
ANOVA (E15 to P60) F(dfbtw, dfw) P<0.0001 NS(p=0.0046) 6.834 (3, 14) NS p<0.0001 37.19 (3, 15) p=0.0003 11.79 (3, 15)
E15 vs P0 NS NS NS
E15 vs P21 P< 0.01 p< 0.001 p< 0.001
E15 vs P60 P< 0.001 p< 0.001 NS
P0 vs P21 P< 0.001 p< 0.001 p< 0.01
P0 vs P60 P< 0.001 p< 0.001 NS
P21 vs P60 NS NS p< 0.05
Cingulate cortex (P0–P60)
D1R D2R D3R D4R D5R
ANOVA (P0 to P60) F(dfbtw, dfw) NS NS NS p<0.0001 392.4 (2, 10) NS
P0 vs P21 p< 0.001
P0 vs P60 p< 0.001
P21 vs P60 NS