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Effect of AT1002 on 3H ardeparin and 14C mannitol fluxes across Caco-2 cell monolayer.
| AT1002 (%) | 3H ardeparin (× 10−7 cm/s) | 14C mannitol (× 10−7 cm/s) | Enhancement ratio (ER) for ardeparin |
|---|---|---|---|
| 0 | 2.8 ± 0.6 | 7.5 ± 3.1 | 1.0 |
| 0.0125 | 4.5 ± 0.2⋆ | 10.4 ± 1.7 | 1.6 |
| 0.0250 | 5.9 ± 0.6⋆ | 14.8 ± 1.0⋆ | 2.1 |
Significantly different compared to control ( p < 0.05).
