. Author manuscript; available in PMC: 2007 Sep 27.

Published in final edited form as: J Drug Target. 2006 Jun;14(5):321–329. doi: 10.1080/10611860600613316

Table II.

Pharmacokinetic parameters following oral administration of ardeparin in rats.

Formulation (route)	C_max (IU/ml)	T_max (min)	AUC_{0–8 h} (IU min/ml)	F_abs (%)	F_rel (%)
Ardeparin alone (oral)	0.13 ± 0.01	232 ± 55	58.5 ± 9.8	2.6 ± 0.4	8.6 ± 1.4
Ardeparin + AT1002 (oral)	0.47 ± 0.06^⋆	300 ± 110^⋆	138.0 ± 4.5^⋆	6.1 ± 0.2*	20.5 ± 0.7^⋆
Ardeparin (i.v.)	0.68 ± 0.02	0	750.3 ± 8.5	100	N/A
Ardeparin (s.c.)	0.61 ± 0.03	120 ± 15	679.9 ± 32.7	90.6	100

^⋆

Significantly different compared to ardeparin alone ( p < 0.05). N/A = not applicable.