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. Author manuscript; available in PMC: 2007 Sep 27.
Published in final edited form as: J Pain. 2007 May 29;8(8):637–649. doi: 10.1016/j.jpain.2007.04.004

Figure 1. The behavioral response to formalin is impaired in diabetic mice.

Figure 1

The behavioral responses of nondiabetic and diabetic mice to formalin injection recorded in 10 min. windows during Phase 1 and Phase 2 of the formalin test prior to sacrifice at 1 (A), 3 (B), 5 (C), and 7 (D) weeks following STZ injection. (A) One week post-STZ, the amount of time devoted to the injected foot did not differ between nondiabetic and diabetic mice. (B) At 3 weeks post-STZ, diabetic mice devoted significantly less time to the injected foot during Phase 2. (C) Diabetic mice displayed significantly reduced behavioral responses during both Phase 1 and 2 at 5 weeks post-STZ. (D) This pattern was maintained during both Phase 1 and 2 at 7 weeks post-STZ. Data plotted as means +/− standard error of mean. * P < 0.05 vs nondiabetic mice, # P < 0.0001 vs nondiabetic mice.