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. Author manuscript; available in PMC: 2007 Sep 27.
Published in final edited form as: Q Rev Biophys. 2006 Jul 19;39(1):57–116. doi: 10.1017/S0033583506004227

Fig. 20.

Fig. 20

AP of different right ventricular cell types. Epicardial cells (top) show a distinct ‘spike and dome’ morphology of the AP, with a deep notch separating spike from dome. M cells from the mid-myocardium (middle) typically have a more shallow notch; their Ito and IKs densities are lower than those of epicardial cells and as a result their AP repolarization phase is easily perturbed by mutations or drugs, or by changes of pacing rate (shown in the figure). Endocardial cells (bottom) do not express Ito and their AP does not display a notch. (From Sicouri & Antzelevitch, 1991, with permission.)