Table 1.

Depression incidence for four hypnotics and parallel placebos

Drug	N subjects	Depression incidence
Zolpidem	353	6
Zolpidem placebo	377	2
Eszopiclone	802	32
Eszopiclone placebo	294	3
Zaleplon	786	24
Zaleplon placebo	277	6
Ramelteon	3594	48
Ramelteon placebo	1370	11
Total of 4 hypnotics	5535*	110 (2.0%)*
Total of 4 placebo groups	2318*	22 (0.9%)*

*Chi Square = 10.04, p < 0.002, risk ratio = 2.1