Table 2.

Results of the overall studies and sub-group studies stratified by ethnicity, quality of control group and comorbidity with Agoraphobia

	na	OR (95% CI)	Significance			Heterogeneity
			Z	p-value	Finner's p	χ2c	p-value	I2
Allelic analyses (s/l)b	10	0.91 (0.80–1.03)	1.47	0.14	0.58	9.75	0.37	7.7%
Ethnicity
Caucasians	6	0.86 (0.74 – 1.01)	1.88	0.06	0.58	4.72	0.45	0%
Asians	4	1.02 (0.81 – 1.27)	0.14	0.89	0.92	3.67	0.30	18.3%
Quality of Control Group
High quality control group	5	0.88 (0.75 – 1.04)	1.52	0.13	0.58	6.51	0.16	38.6%
Low quality control group	5	0.96 (0.78 – 1.17)	0.43	0.67	0.76	2.87	0.58	0%
Agoraphobia comorbidity
With Agoraphobia	4	0.94 (0.77 – 1.15)	0.57	0.57	0.69	5.21	0.16	42.4%
Without Agoraphobia	3	0.80 (0.60 – 1.08)	1.48	0.14	0.58	2.30	0.32	12.9%
Genotype (ls+ss) vs. ll	10	0.87 (0.71 – 1.06)	1.39	0.17	0.58	7	0.64	0%
Ethnicity
Caucasians	6	0.85 (0.68 – 1.05)	1.48	0.14	0.58	4.36	0.50	0%
Asians	4	1.01 (0.55 – 1.86)	0.03	0.98	0.98	2.56	0.46	0%
Quality of Control Group
High quality control group	5	0.80 (0.63 – 1.03)	1.76	0.08	0.58	3.72	0.45	0%
Low quality control group	5	1.02 (0.71 – 1.46)	0.11	0.91	0.93	2.30	0.68	0%
Agoraphobia comorbidity
With Agoraphobia	4	0.80 (0.57 – 1.11)	1.32	0.19	0.58	2.90	0.41	0%
Without Agoraphobia	3	0.85 (0.51 – 1.40)	0.65	0.51	0.67	1.18	0.55	0%

Abbreviations: OR, odds ratio (fixed effect); Q, Cochran's x²-based Q statistic test used to assess the heterogeneity; z test used to determine the significance of the overall OR; I², inconsistency; Finner's p-value, adjusted p-value for multiple comparison

^a The number of studies included are indicated

^b The first allele is the risk allele

^c Degrees of freedom = number of studies - 1.