Table II.

Protein-protein interactions among base excision repair proteins

BER Proteins	Interacting Proteins	Citation
UNG1	NDa	-
UNG2	PCNA, RPA, Vpr	[139-141]
SMUG	Vpr	[141]
TDG	APE1, p300, XPC/HR23B	[26, 27, 142]
MBD4	ND
Aag/MPG	XRCC1, HR23A, MBD1	[28, 143, 144]
OGG1	XRCC1, CSB	[34, 145]
OGG2	ND	-
MYH	APE1, PCNA, RPA	[32, 146]
MTH	ND	-
NTH1	XPG	[147, 148]
NEIL1	pol ß, LigIIIα	[23]
NEIL2	pol ß, LigIIIα, PNKP, XRCC1	[23]
NEIL3	ND	-
APE1	TDG, MYH, pol ß, LigI, Fen1, PCNA, p53, GzmA	[26, 38, 40, 42, 43, 142, 149-151]
APE2	ND	-
pol ß	APE1, LigI, Fen1, PCNA, PARP1, PARP2, PNKP, NEIL1, NEIL2, Aprataxin, p53, Trf2, p300, XRCC1, PRMT1, PRMT6	[12, 17, 23, 63, 66, 75, 88, 113, 119, 128, 129, 149, 150, 152-157]
LigI	APE1, pol ß, PCNA	[43, 152, 158, 159]
LigIIIα	XRCC1, PARP1, PARP2, PNKP, NEIL1, NEIL2, Aprataxin	[15, 18, 63, 66, 75, 113]
Fen1	APE1, pol ß, PCNA, PARP1, p300, WRN, BLM	[12, 42, 43, 123, 160-164]
PCNA	APE1, pol ß, PARP1, XRCC1, p300, CSB, WRN	[19, 42, 139, 140, 146, 155, 158-161, 165-170]
XRCC1	MPG, OGG1, APE1, pol ß, LigIIIα, PARP1, PARP2, PNKP, Tdp1, Aprataxin	[15, 23, 28, 34, 40, 60, 61, 63, 66, 72-76, 113]
PNKP	pol ß, LigIIIα, XRCC1, NEIL1, NEIL2	[63]
PARP1	pol ß, PCNA, XRCC1, p300, CSB, WRN, Ku, LigIIIα	[12, 16-19, 74, 87, 113, 157, 171-173]
PARP2	pol ß, LigIIIα, PARP1, XRCC1	[113]
Aprataxin	pol ß, LigIIIα, PARP1, XRCC1	[72-76]
Tdp1	XRCC1	[61]

^aND – No interacting proteins identified to date.