Table III.
Post translational modifications of BER proteins
| Function | Protein | Phosphorylation | Acetylation | Sumoylation | Ubiquitylation | Methylation |
|---|---|---|---|---|---|---|
| Lesion Recognition and Strand Scission | TDG | C--[26] | A--[99-101, 174] | |||
| UNG2 | A--[175]; C--[176, 177] | B--[176] | ||||
| MPG | A--[178] | |||||
| MYH | A--[98] | |||||
| NEIL2 | B--[102] | |||||
| OGG1 | B--[96]*; C--[96, 179] | |||||
| APE1 | B--[107]**; C--[103-107, 126] | C--[109, 110] | ||||
|
| ||||||
| BER scaffold | XRCC1 | A--[75, 115, 116] | C--[117] | |||
| Parp1 | A--[180] | A--[181] | C--[117] | [182] | ||
|
| ||||||
| Gap Tailoring | pol ß | A--[127]; [126] | B--[119] | |||
| Fen1 | B--[121] | B--[122]; C--[123] | ||||
| WRN | B--[183-187] | A--[125] | C--[188]## and [189] | |||
|
| ||||||
| DNA Synthesis and Ligation | pol ß | A--[127] | A--[128]# | |||
| LigI | C--[130] | |||||
| LigIIIα | C--[131] | |||||
| PCNA | A--[190] | A--[156] | C--[191, 192] | A--[193]; C--[194] | ||
A - Denotes Increased Catalytic Efficiency
B - Denotes Decreased Catalytic Efficiency
C - No Effect Shown
*
Specific for Cdk4 phosphorylation only
**
Specific for CKII phosphorylation only
#
Stimulated DNA binding and processivity; single nucleotide insertion and 5’dRP lyase activity were not affected
##
Mouse homolog identified as substrate for modification