Fig. 3.

Leptin stimulates an increase in neurite length. (A) Confocal images of a hippocampal neuron (11 DIC) transiently transfected with cytosolic EGFP. The region of interest in panel Ai is magnified and displayed in panel Aii. In control conditions (in the absence of leptin), there is little or no change in the length of the neurite. However, application of leptin (50 nM) to the same neuron rapidly stimulated elongation of the same process. (B) Pooled data illustrating the mean increase in the relative length of protruding neurites following leptin treatment. *P < 0.05.