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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Mol Immunol. 2007 Feb 14;44(11):2988–2996. doi: 10.1016/j.molimm.2006.12.026

Figure 5.

Figure 5

Presentation of a CII-derived peptide, HII-44 (554−573), and its minimal epitope by B and dendritic cells to antigen-specific and DQ8-restricted T cell hybridoma shows B cells can present the peptide. A) T cell proliferation in vitro with peptide 554−573 and its minimal epitope presented by APCs. B) B cells and dendritic cells isolated from naïve mice and mice primed with HII-44 and minimal peptide 44S were cultured in vitro with T cells hybridoma specific for HII-44 in the presence or absence of the peptides. IL-2 levels were measured by ELISA from the in vitro culture supernatants after 24 hrs. Also, B and dendritic cells were pre-incubated with the peptides HII-44 and HII-44S for 24 hrs, washed and then used as antigen presenting cells to specific hybridoma without the presence of peptide. *p<0.05.