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Uptake of [14C]-erythromycin in the presence of unlabeled cyclosporine-A (25 and 50 μM) in rPCEC and SV40-HCEC. Each data point represents the mean ± SD of three determinations. Statistical significance was tested by two-factor ANOVA. *P ≤ 0.05; **P ≤ 0.01.