Table 3. Permeabilities Organized by Molecular Permeant.
| ATP | 26h (Tran Van Nhieu et al., 2003) | 3a 3b 3e (purinergic block had only partial effect) |
| 26h or 26/30h (Zhao et al., 2005) | 3a 3c | |
| 26h or 43h (Gomes et al., 2005) | 3a 3c 3d 5 | |
| 32h (Cotrina et al., 1998) | 3a 3b 3c (connexin block had only partial effect) | |
| 32h (Cotrina et al., 2000) | 3b 3c | |
| 32h (Belliveau et al., 2006) | 3a 3b | |
| 32h (De Vuyst et al., 2006) | 3a 3b 3d 3e (peptide work in question; cytoplasmic peptide had effect from extracellular medium) | |
| 38h (Bahima et al., 2006) | 3a 3b 3c | |
| 43h (Cotrina et al., 1998) | 3a 3b 3c (connexin block had only partial effect) | |
| 43h (Cotrina et al., 2000) | 3b 3c | |
| 43h (Romanello and D'Andrea P, 2001) | 3a 3c 3e | |
| 43h (Stout et al., 2002) | 3a 3b 3c | |
| 43h (Pearson et al., 2005) | 3a 3d 3e | |
| 43h (Belliveau et al., 2006) | 3a 3b | |
| 43h (Eltzschig et al., 2006) | 3a 3d | |
| φ 43h during Ca waves (Suadicani et al., 2006) | ||
| pan1h (Bao et al., 2004; Locovei et al., 2006) | ||
| ADP or ATP | 43j (Goldberg et al., 1998; Goldberg et al., 1999) | 1a 6 |
| 43j (Goldberg et al., 2002) | 1b 6 | |
| 43j ≫ 32j(∼0.01) (Goldberg et al., 1999) | 1a 6 | |
| 43j > 32j(0.14) (Goldberg et al., 2002) | 1b 6 | |
| AMP | ||
| 43j ≫ 32j (Goldberg et al., 2002) | 1b 6 | |
| 43j > 32j(0.14) (Goldberg et al., 2002) | 1b 6 | |
| adenosine | 32j (Goldberg et al., 2002) | 1b 6 |
| φ43j (Goldberg et al., 2002) | 1b 6 | |
| aspartate | 26h or 30h or 26/30h or 43h (Ye et al., 2003) | 3a 3c 3e 5 |
| cAMP | 26h (Locke et al., 2004) | 3f |
| 26j (Hernandez et al., 2007) | 1a 1b | |
| 26/32h (Bevans et al., 1998; Locke et al., 2004) | 3f (not permeable through all the heteromeric channels) | |
| 32h (Bevans et al., 1998; Locke et al., 2004) | 3f | |
| 43h (Kam et al., 1998) | 3f | |
| 43j (Ponsioen et al., 2007) | 1a | |
| 43/46j (Qu and Dahl, 2002) | 1a (not permeable through substate) | |
| 46h (Qu and Dahl, 2002) | 3b (not permeable through substate) | |
| 43j > 26j(0.34) > 45j(0.21) = 32j(0.18) > 47j(0.14) ≫ 36j(0.03) (Bedner et al., 2003; Bedner et al., 2006) | 1a | |
| cGMP | 26h (Locke et al., 2004) | 3f |
| 26/32h (Bevans et al., 1998; Locke et al., 2004) | 3f (not permeable through all the heteromeric channels) | |
| 32h (Bevans et al., 1998; Locke et al., 2004) | 3f | |
| Ca++ | 32j (Sáez et al., 1989) | 2 5 |
| 37j or 37/43j or 43j (Christ et al., 1992) | 1a 2 5 | |
| glucose | ||
| 43j > 32j(0.23) (Goldberg et al., 2002) | 1b 6 | |
| glutamate | 26h or 30h or 26/30h or 43h (Ye et al., 2003) | 3a 3c 3e 5 |
| 32h (Takeuchi et al., 2006) | 3a 3d | |
| 43j > 32j(0.12) (Goldberg et al., 2002) | 1b 6 | |
| 43j ≫ 32j(0.03) (Goldberg et al., 1999) | 1a 6 | |
| glutathione | ||
| 43j > 32j(0.23) (Goldberg et al., 2002) | 1b 6 | |
| 43j ≫ 32j(0.03) (Goldberg et al., 1999) | 1a 6 | |
| IP3 | 26h (Locke et al., 2004; Ayad et al., 2006) | 3f |
| 26j (Niessen and Willecke, 2000) | 2 | |
| 26j (Paemeleire et al., 2000) | 1b 2 | |
| 26j (Beltramello et al., 2005) | 1a 1b 2 | |
| 26j (Hernandez et al., 2007) | 1a 1b | |
| 26j or 26/30j (Zhang et al., 2005) | 1a 1b 2 (Ca injection used to rule out Ca flux) | |
| 26/32h (Locke et al., 2004) | 3f (not permeable through all heteromeric channels) | |
| 26/32h (Ayad et al., 2006) | 3f (not permeable through all the heteromeric channels; differential permeability among inositol triphosphate isoforms) | |
| 26/32j or 32j (Niessen and Willecke, 2000) | 2 | |
| 26/32j or 32j (Clair et al., 2001) | 1a 2 (Ca flux ruled out as causing Ca signaling) | |
| 32h (Locke et al., 2004; Ayad et al., 2006) | 3f | |
| 32j (Brehm et al., 1989) | 2 5 | |
| 32j (Paemeleire et al., 2000) | 1b 2 | |
| 43h (Kam et al., 1998) | 3f | |
| 43h (Romanello and D'Andrea P, 2001) | 3a 3c 3e | |
| 43j (Venance et al., 1997) | 1a 1b 2 5 | |
| 43j (Paemeleire et al., 2000) | 1b 2 | |
| 43j (Romanello and D'Andrea P, 2001) | 1a 1b 2 | |
| 32j > 43j > 26j (Niessen et al., 2000) | 1b 2 (normalized by Mn spread, not junctional conductance) | |
| mobile pH buffers | 43j (Swietach and Vaughan-Jones, 2004) | 1a 5 7 |
| NAD+ | 43h (Bruzzone et al., 2001a; Bruzzone et al., 2001a) | 3a 3b 3c 3f |
| peptides ≤ 10mers | 43j (Neijssen et al., 2005) | 1a |
| prostaglandin E2 | 43h (Jiang and Cherian, 2003; Cherian et al., 2005) | 3a 3b 3c 3e |
| RNA 12mer | φ 26/32j (Valiunas et al., 2005) | 1a |
| 43j (Valiunas et al., 2005) | 1a | |
| RNA 16mer | 43j (Valiunas et al., 2005) | 1a |
| RNA 24mer | 43j (Valiunas et al., 2005) | 1a |
| dsRNA 12mer | φ 43j (Valiunas et al., 2005) | 1a |
| siRNA 22mer | φ 26/32j (Valiunas et al., 2005) | 1a |
| 43j (Valiunas et al., 2005) | 1a |
5
Connexin identity inferred.
6
Due to metabolic issues, in this study there is some ambiguity of the identities of the compounds that actually permeated the junctional channels. ATP could contribute to the measurement of ADP, AMP and adenosine, and glutamate could contribute to the glutathione measurement. Therefore the relative permeabilities reported may be artifactually skewed toward the downstream metabolic products, resulting in the appearance of lesser relative permeability to ADP/ATP and to glutamate.
7
Mobile pH buffers are phosphate, homocarnosine, taurine, and acetylated derivatives of anserine, carnosine and histidine (Vaughan-Jones et al., 2002).