Table 2.
Neutral evolution robustness and mutation data. Each row represents a different generation, T. NA indicates that no measurement was made. The <mnt> and <maa> are the average number of nucleotide mutations and nonsynonymous mutations, respectively. Numbers in parentheses are total counts over the total samples. Subscripts indicate the population type: U for unselected, P for polymorphic, and M for monomorphic. For the unselected and monomorphic populations, numbers represent averages of all replicates. For the polymorphic population, numbers are for a random sample of functional mutants. <F>P and <F>M are the fraction of functional mutants out of 435 assayed.
| T | <mnt>U | <maa>U | <mnt>P | <maa>P | <mnt>M | <maa>M | <F>P | <F>M |
| 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.48 (210/435) | 0.48 (210/435) |
| 1 | NA | NA | NA | NA | 0.1 (3/22) | 0.3 (6/22) | 0.48 (208/435) | NA |
| 2 | NA | NA | NA | NA | 0.4 (9/22) | 0.8 (17/22) | 0.49 (215/435) | NA |
| 3 | 5.0 (20/4) | 3.5 (14/4) | 2.7 (27/10) | 1.4 (14/10) | 1.0 (23/22) | 0.4 (9/22) | 0.49 (215/435) | NA |
| 4 | NA | NA | NA | NA | 1.5 (32/22) | 0.7 (15/22) | 0.48 (208/435) | NA |
| 5 | NA | NA | NA | NA | 2.2 (48/22) | 1.1 (25/22) | 0.45 (197/435) | 0.43 (185/435) |
| 6 | 9.8 (39/4) | 7.5 (30/4) | 5.5 (55/10) | 2.1 (21/10) | 2.6 (58/22) | 1.4 (31/22) | 0.46 (198/435) | NA |
| 7 | NA | NA | NA | NA | 3.1 (69/22) | 1.8 (39/22) | 0.52 (227/435) | NA |
| 8 | NA | NA | NA | NA | 3.4 (74/22) | 1.8 (40/22) | 0.46 (200/435) | NA |
| 9 | 13.0 (52/4) | 10.3 (41/4) | 6.7 (61/9) | 3.1 (28/9) | 3.7 (82/22) | 2.1 (46/22) | 0.47 (203/435) | NA |
| 10 | NA | NA | NA | NA | 4.2 (92/22) | 2.4 (52/22) | 0.46 (199/435) | 0.40 (175/435) |
| 11 | NA | NA | NA | NA | 4.6 (102/22) | 2.5 (56/22) | 0.48 (207/435) | NA |
| 12 | 16.8 (67/4) | 12.5 (50/4) | 7.8 (70/9) | 3.3 (30/9) | 4.9 (107/22) | 2.6 (58/22) | 0.52 (228/435) | NA |
| 13 | NA | NA | NA | NA | 5.0 (110/22) | 2.7 (60/22) | 0.52 (227/435) | NA |
| 14 | NA | NA | NA | NA | 5.3 (116/22) | 2.9 (64/22) | 0.50 (216/435) | NA |
| 15 | NA | NA | 10.3 (227/22) | 3.8 (83/22) | 5.6 (123/22) | 3.0 (67/22) | 0.50 (219/435) | 0.39 (171/435) |
| 16 | NA | NA | NA | NA | 5.8 (127/22) | 3.0 (67/22) | NA | NA |
| 17 | NA | NA | NA | NA | 6.0 (133/22) | 3.1 (69/22) | NA | NA |
| 18 | NA | NA | NA | NA | 6.3 (137/22) | 3.2 (71/22) | NA | NA |
| 19 | NA | NA | NA | NA | 6.3 (138/22) | 3.3 (72/22) | NA | NA |
| 20 | NA | NA | NA | NA | 6.6 (145/22) | 3.4 (75/22) | NA | 0.37 (160/435) |
| 21 | NA | NA | NA | NA | 6.9 (152/22) | 3.6 (79/22) | NA | NA |
| 22 | NA | NA | NA | NA | 7.1 (156/22) | 3.7 (81/22) | NA | NA |
| 23 | NA | NA | NA | NA | 7.2 (158/22) | 3.7 (81/22) | NA | NA |
| 24 | NA | NA | NA | NA | 7.3 (161/22) | 3.8 (83/22) | NA | NA |
| 25 | NA | NA | NA | NA | 7.7 (169/22) | 4.0 (87/22) | NA | 0.39 (169/435) |